This article goes over: A Family History of High Cholesterol A SAFEHEART Perspective.

This ongoing registry of molecularly characterized patients with heterozygous FH in Spain is known as SAFEHEART (Spanish Familial Hypercholesterolaemia Cohort Study). Individual traits, genetic factors, lipid-lowering treatments, and ASCVD in the various arterial areas were all included of the analysis. Of the 4132 participants in the study, 3,745 were adults aged 18 and above, and 2,752 of them were cases of FH that had been molecularly identified. In FH patients, the median age was 44.0 years (45.9% men) whereas in unaffected relatives, it was 40 years (46.6% men) (P<0.001). 358 (or 13.0%) FH patients and 47 (or 4.7% of unaffected relatives) had ASCVD, respectively (P<0.001). Patients with FH were more likely to have a history of early ASCVD (9.4% vs. 2.4% in families unaffected by FH; P<0.001). While there were no statistically significant differences in cerebrovascular events between FH patients and controls, there were higher cases of peripheral artery disease and symptoms associated to the coronaries in the former group. Independent risk factors for ASCVD included advanced age, obesity, type 2 diabetes mellitus, hypertension, a history of cigarette smoking, and lipoprotein(a) >50 mg/dL.

Ischemic heart disease is a symptom of heterozygous familial hypercholesterolemia (FH), the most prevalent monogenic illness connected to early atherosclerotic cardiovascular disease (ASCVD). How much of a risk FH has for peripheral arterial and cerebrovascular disease is unknown. Our objective was to examine the features and prevalence of ASCVD in various arterial areas within a sizable FH population, compare these data to those of a control group that was not affected, and identify the factors that are linked to ASCVD.

Compared to their unaffected relatives, FH patients had a higher frequency of ASCVD and varied involvement of the arterial regions. Coronary artery disease (CAD) was found to be independently linked with age, male sex, increased body mass index, hypertension, type 2 diabetes mellitus, smoking habit, and lipoprotein.

Having a Family History of High Cholesterol  is nothing to be afraid of. Always be sure to talk to your doctor if you have concerns.

Read up on the entire study Here!

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